Results
| PMID | 10899494 |
| Gene Name | INHB |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 30 |
| Population details | 30 (20 women with endometriosis, 10 with tubal factor) |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Endometriosis, Infertility |
|
Fertil Steril. 2000 Jul;74(1):35-40. Dokras, A| Habana, A| Giraldo, J| Jones, E Yale University School of Medicine, New Haven, Connecticut, USA. anuja-dokras@iowa.edu OBJECTIVE(S): To determine the levels and pattern of inhibin B secretion during ovarian stimulation in patients with endometriosis and to evaluate the correlation between inhibin B levels and variables of follicular and oocyte development. DESIGN: Retrospective cohort study. SETTING: IVF center. PATIENT(S): Women with endometriosis (n = 20) and tubal factor (n = 10) as the only cause of infertility. INTERVENTION(S): Inhibin B levels were measured during gonadotropin stimulation on day 1, days 8-11, day of hCG administration, and oocyte retrieval. MAIN OUTCOME MEASURE(S): Patterns and levels of inhibin B secretion were compared in the two groups. Other variables analyzed were age, days of gonadotropin stimulation and total ampules used, oocytes retrieved, and the fertilization and pregnancy rate. RESULT(S): Inhibin B levels and number of oocytes retrieved were significantly lower in patients with endometriosis than in the control group. Two patterns of inhibin B secretion were noted: It peaked in the midfollicular phase or on the day of hCG administration. In contrast, E2 levels peaked on the day of hCG administration. Inhibin B in the midfollicular phase in both groups correlated positively with number of oocytes retrieved. In addition, E2 and inhibin B levels in the midfollicular phase correlated positively. CONCLUSION(S): Decreased inhibin B secretion in patients with endometriosis suggests impaired granulosa cell function. Inhibin B may serve as an alternate marker to assess follicular development or to predict the number of oocytes retrieved. Mesh Terms: Adult| Biomarkers| Cohort Studies| Endometriosis/complications/*metabolism| Estradiol/metabolism| Female| Granulosa Cells/physiology| Humans| Infertility, Female/complications/*metabolism| Inhibins/*secretion| *Ovulation Induction| Pregnancy| |
|